No, you do not have to refrigerate our CBD Oil. Most people use their bottle or vape within a few months and no refrigeration is needed. If you are going to store your oil for long periods of time, then yes keep it in the fridge. Without refrigeration our extract maintains it's potency for about 8 to 10 months because we are fresh, raw hemp without any additives of any kind! When the oil is kept inside the refrigerator you won't start losing any potency for about 2 years (24 months). The oil will never spoil or harm you, only start to lose it's cannabinoids, and terpenes potency above these guidelines. At our facility we always refrigerate all our extract awaiting to be bottled, and after bottling up until the day we ship, so that you are receiving the most fresh product possible.